NOVEL ANTIMICROBIAL PEPTIDES

摘要

This invention involves two novel peptides of the formulas (1) H-Gly -Met-Trp -Ser-Lys- -Ile-Leu-Gly -His-Leu-Ile-Arg -NH2 and (2), H-Gly -Lys-Trp -Met-Ser-Leu-Leu-Lys -His-Ile-Leu-Lys-NH2 isolated from natural sources and their synthetic analogs of general formula (1-A) [Xaan]m -Gly-Met-Trp-Ser-Lys-Ile-Leu-Gly-His-Leu-Ile-Arg-NH2 and (2-A), [Xaan]m -Gly-Lys-Trp-Met-Ser-Leu-Leu-Lys-His-Ile-Leu-Lys-NH2 where Xaa represents, independently from each other, proteinogenic amino acid, D-amino acid, non- standard amino acid or amino acid with the side chain modification, n means position of the amino acid replacement and m means the number of the replacements in the peptide chain. Described is also their use for the preparation of medicaments for the treatment of microbial, parasitic and fungal diseases and for the cancer treatment.