COMPOSITION OF PERMEATION ENHANCER AND USE THEREOF IN TRANSDERMAL DRUG DELIVERY SYSTEM

摘要

A permeation enhancer and its use in the transdermal drug delivery system. The permeation enhancer comprises ethers and alcohols which are not C6-C18 fatty alcohols. It may further contains C6-C18 fatty acids or C6-C18 fatty alcohols. The ether compound is selected from dimethyl isosorbide, diethylene glycol monoethyl ether or diethylene glycol monomethyl ether. The alcohol compound is selected from propylene glycol, polyethylene glycol or benzyl alcohol. The permeation enhancer does not comprise DMSO.