SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION

摘要

Compounds according to the invention are 2-(3-Q5-4-Q4-5-Q3-thien-2-yl)-4-R3-5-R2-1,3-thiazol, 2-(3-Q5-4-Q4- 5-Q3-fur-2-yl)-4-R3-5-R2-1,3-thiazol, 2-(3-Q5-4-Q4-5-Q3-thien-2-yl)-5-R2-1,3,4-thiadiazol, 2-(3-Q5-4-Q4-5-Q3-fur-2-yl)-5-R2-1,3,4-thiadiazol, 2-(2-Q3-4-Q5-1,3-thiazol-5-yl)4-R3-5-R2-1,3-thiazol, 2-(2-Q3-4-Q5-1,3-oxazol-5-yl)4- R3-5-R2-1,3-thiazol, 2-(4-Q4-5-Q3-1,3-thiazol-2-yl)4-R3-5-R2-1,3-thiazol, 2-(4-Q4-5-Q3-1,3-oxazol-2-yl)4-R3-5- R2-1,3-thiazol, 2-(4-Q5-5-Q4-3-Q2-thien-3-yl)4-R3-5-R2-1,3-thiazol, 2-(4-Q5-5-Q4-3-Q2-fur-3-yl)4-R3-5-R2-1,3-thiazol, 2-benzo[b]thiophen-2-yl4-R3-5-R2-1,3-thiazol, 2-benzo[b]furan-2-yl4-R3-5-R2-1,3-thiazol, 2-(3-Q5-4- Q4-5-Q3-thien-2-yl)-6-Z2-1,3-benzo[d]thiazol, 2-(3-Q5-4-Q4-5-Q3-thien-2-yl)-6-Z2-1,3-benzo[d]oxazol, 2-(2-Z5-3- Z6-4-Z7-phenyl)4-R3-5-R2-1,3-thiazol, 2-(5-Z8-6-Z7-3-pyridyl)4-R3-5-R2-1,3-thiazol, 2-(3-R3-4-R2-phenyl)-3-Q5- 4-Q4-5-Q3-thiophen, 2-(3-R3-4-R2-phenyl)-3-Q5-4-Q4-5-Q3-furan, N-Z9-N-(4-R3-5-R2-1,3-thiazol-2-yl)-3-Q5-4-Q4- 5-Q3-thien-2-yl-carboxamid, N-Z9-N-(4-R3-5-R2-1,3-thiazol-2-yl)-3-Q5-4-Q4-5-Q3-fur-2-yl-carboxamid, 5-(3-Q5-4- Q4-5-Q3-thien-2-yl)4-R4-2-R2-1,3-thiazol, 5-(3-Q5-4-Q4-5-Q3-fur-2-yl)4-R4-2-R2-1,3-thiazol, 2-(3-Q5-4-Q4-5-Q3- thien-2-yl)-3-R4-4-R3-5-R2-thiophen, 2-(3-Q5-4-Q4-5-Q3-fur-2-yl)-3-R4-4-R3-5-R2-thiophen; wherein R2, R3, R4, Q2, Q3, Q4, Q5, Z2, Z5, Z6, Z7, Z8 and Z9 are as defined in the description. Said compounds are particularly advantageous for treating and/or preventing influenza type A and/or influenza type B infections in humans, mammals and/or birds, and for treating and/or preventing respiratory syncytial virus infections in humans, mammals and/or birds.