发明名称 |
Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts |
摘要 |
<p>The present invention relates to non-hydrate crystalline forms of 4-amino- 5-fluoro-3 -[6-(4-methylpiperazin- 1-yl)- 1H-benzimidazol-2-yl] - 1H-quinolin-2-one lactic acid salts, solid pharmaceutical formulations containing the same and methods of use. The present invention also relates to crystalline hydrates of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts, pharmaceutical formulations containing the same and methods of use related thereto. The present invention further relates to crystalline solvates of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts.</p> |
申请公布号 |
EP2270000(A1) |
申请公布日期 |
2011.01.05 |
申请号 |
EP20100178683 |
申请日期 |
2006.05.23 |
申请人 |
NOVARTIS AG |
发明人 |
OKHAMAFE, AUGUSTUS;CHOU, JOYCE;GULLAPALLI, RAMPURNA;HARWOOD, ERIC;RYCKMAN, DAVID;ZHU, SHUGUANG;SHANG, XIAO |
分类号 |
C07D401/04;A61K31/496 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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