CONJUGATES OF PEPTIDES AND PEPTIDE MIMETICS HAVING INTEGRIN INHIBITOR PROPERTIES

摘要

The invention relates to compounds of formula (1) B-Q-X1, wherein B is a bioactive, cell adhesive mediating molecule, Q is absent or is an inorganic spacer molecule and X1 is an anchor molecule, selected from the group Lys-(CO-CH2-(CH2)n-PO3H2)2 (I), -Lys-[Lys-(CO-CH2-(CH2)n-PO3H2)2]2 (ii) or -Lys-(Lys[-Lys-(CO-CH2-(CH2)n-PO3H2)2]2 (iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X1. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.