发明名称 |
METODOS Y COMPOSICIONES PARA MODULAR LA FOSFORILACION DE LA BETA-CATENINA. |
摘要 |
The present invention provides modulators of beta -catenin phosphorylation. More specifically, the present invention provides inhibitors and enhancers of beta -catenin Serine 45 (S45) phosphorylation. Examples of inhibitors provided by the invention are the proteins Dishevelled (Dvl), Wnt, phosphatase PP2A and CKI7. Examples of enhancers of beta-catenin phosphorylation are phosphatase inhibitors and proteins that promote -catenin acetylation, like FRAT1. In addition, the present invention provides compositions and uses of the modulators of the invention, specifically for the treatment of cancer, as well as a method for screening such modulators.
|
申请公布号 |
ES2349498(T3) |
申请公布日期 |
2011.01.04 |
申请号 |
ES20030717515T |
申请日期 |
2003.04.28 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM |
发明人 |
BEN-NERIAH, YINON;AMIT, SHARON;BIRMAN, YAARA;HATZUBAI, ADA;ALKALAY, IRIT |
分类号 |
A61K38/02;A61K38/17;A61K38/46;A61P35/00 |
主分类号 |
A61K38/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|