| 发明名称 |
NITROANILINE-BASED ALKYLATING AGENTS AND THEIR USE AS PRODRUGS |
| 摘要 |
Nitroaniline-based unsymmetrical mustards of the general formula (I) ((see formula I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjuction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents.
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| 申请公布号 |
CA2501388(C) |
申请公布日期 |
2011.01.04 |
| 申请号 |
CA20032501388 |
申请日期 |
2003.10.08 |
| 申请人 |
AUCKLAND UNISERVICES LIMITED |
发明人 |
DENNY, WILLIAM ALEXANDER;ATWELL, GRAHAM J.;YANG, SHANGJIN;WILSON, WILLIAM ROBERT |
| 分类号 |
C07C237/30;A61K31/166;A61K31/18;A61K31/357;A61K31/5375;A61P35/00;C07C309/66;C07C311/39;C07D263/04;C07D295/13;C07D317/28 |
主分类号 |
C07C237/30 |
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