Method of producing N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenylpropylamine in its racemic or optically active form

摘要

Disclosed is a process for preparing N,N-diisopropyl-3-(2- hydroxy-5-methylphenyl)-3-phenylpropyl amine (tolterodine) of formula (I) in racemic or optically active form thereof wherein the preparation process comprises synthesis of enantiomerically enriched compounds (R)- and (S)-3,4-dihydro-6-methyl-4-phenyl-2H- benzopyran-2-one of the general formulae (II-R) and (II-S) and preparation of 3-(2-hydroxy-5-methylphenyl)-3-phenylpropanol in racemic or enantiomerically enriched form of formulae (VIII) or (VIII-R) and (VIII-S), protected on both oxygen atoms with sulfoester group.