Control of gene expression

摘要

In the present invention, there is disclosed a synthetic gene containing a dispersed or foreign deoxyribonucleic molecule, said gene comprising at least two copies of a structural gene sequence where at least 80 percent of the first copy of the structural gene sequence is identical with a nucleotide sequence of the target gene section and at least 80 percent of the second copy of the structural gene sequence is identical with a nucleotide sequence being complementary to a target gene section and wherein the synthetic gene is capable of post-transcription repressing, delaying or otherwise reducing the expression of said target gene if it is exprimed in a host cell of a mammal by sequentially-specific degradation of RNA transcription of the target gene by an endogenous host cell system. These synthetic genes and gene constructs are capable of repressing, delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism in which they are introduced. The present invention also relates to a gene construct containing such a synthetic gene and a preparation comprising said synthetic gene.