发明名称 |
METHODS OF THERAPY FOR SOLID TUMORS EXPRESSING THE CD40 CELL-SURFACE ANTIGEN |
摘要 |
<p>Methods of therapy are provided for treating a subject for a solid tumor that comprises carcinoma cells expressing the CD40 cell-surface antigen. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a subject in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Binding of the anti-CD40 antibody or suitable antigen-binding fragment thereof beneficially inhibits growth of solid tumors via ADCC-dependent killing of the CD40-expressing carcinoma cells.</p> |
申请公布号 |
SI1680141(T1) |
申请公布日期 |
2010.12.31 |
申请号 |
SI20040031526T |
申请日期 |
2004.11.04 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC.;XOMA TECHNOLOGY LTD. |
发明人 |
LONG LI;LUQMAN MOHAMMAD;YABANNAVAR ASHA;ZAROR ISABEL |
分类号 |
A61K39/395;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|