AMORPHOUS ADEFOVIR DIPIVOXIL SOLID DISPERSION HAVING ENHANCED STABILITY AND PREPARATION METHOD THEREOF
摘要
PURPOSE: A method for preparing amorphous adefovir dipivoxil solid dispersion with improved stability is provided to ensure high elution rate and to prevent or treat chronic hepatitis type B. CONSTITUTION: An adefovir dipivoxil solid dispersion with improved stability contains adefovir dipivoxil and hydrophilic polymer. Adefovir dipivoxil solid dispersion is amorphous. A method for preparing adefovir dipivoxil solid dispersion comprises: a step of completely dissolving adefovir dipivoxil and hydrophilic polymer in a solvent; and a step of drying the solution to preparing a solid dispersion. An oral solid formulation for treating acute hepatitis type B contains adefovir dipivoxil solid dispersion. The oral solid is granule or tablet.
申请公布号
KR20100138114(A)
申请公布日期
2010.12.31
申请号
KR20090056492
申请日期
2009.06.24
申请人
DAE WON PHARMACEUTICAL CO., LTD.
发明人
WON, KYUNG JAE;MO, SEI MYOUNG;CHAE, BO RAM;SONG, SE HYUN;SOHN, SE IL