PHARMACEUTICAL COMPOSITIONS COMPRISING ALENDRONATE AND POLYETHYLENE GLYCOL, AND PREPARATION METHODS

摘要

PURPOSE: A pharmaceutical composition containing alendronate and polyethylene glycol is provided to improve drug penetration rate. CONSTITUTION: A pharmaceutical composition for preventing and treating bone diseases contains 0.5-5 weight% of alendronate, 65-95 weight% of polyethylene glycol, and 2.5-30 weight% of steraroyl macrogolglyceride. The composition further contains 1.5-15 weight% of surfactant, 0.1-30 weight% of distilled water and 0.4-3 weight% of sodium chloride. A pharmaceutical composition is prepared by mixing alendronate, polyethylene glycol and steraroyl macrogolglyceride and dissolving at 80-100 °C.