| 摘要 |
A bicyclic cinnamide compound represented by the formula (I):whereinindicates a single bond or double bond; Arrepresents phenyl or pyridinyl optionally substituted by one to three substituents; Rand Reach represents C1-6 alkyl, hydroxy, etc.; Zrepresents optionally substituted methylene or vinylene, oxygen, or imino optionally substituted by C1-6 alkyl or C1-6 acyl; and p, q, and r each is an integer of 0-2. It functions to reduce the production of A&bgr;40 and A&bgr;42. It is hence useful especially as a preventive or remedy for neurodegenerative diseases of which A&bgr; is causative, such as Alzheimer's disease and Down's syndrome. |
