发明名称 |
EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS |
摘要 |
Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.
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申请公布号 |
US2010331390(A1) |
申请公布日期 |
2010.12.30 |
申请号 |
US20100720581 |
申请日期 |
2010.03.09 |
申请人 |
GENZYME CORPORATION |
发明人 |
CROOKE ROSANNE M.;GRAHAM MARK J. |
分类号 |
A61K48/00;A61K38/00;A61P3/04;A61P9/00;C07H21/04;C12N5/02;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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