| 摘要 |
The invention relates to compounds of the general formula (I) and salts and stereoisomers thereof, wherein Y is imidazolidin-1-yl-2,4-dione; n is 1 or 4; m is 0 or 1; r is 1; t is 1; X is O or N; Z is C=O; Zis (CH)-R; Zis (CH)-R; Zis (CH)-R; Zis H or methyl; Ris phenyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazolyl indolyl, imidazolyl, 4-tetrahydro-thieno[3,4-d]imidazol-2-on-yl, 4-phenoxy-benz-l-yl, which are optionally substituted by halogen, alkoxy, haloalkyl or haloalkoxy; R, Rand Rare H, phenyl, benzyl, 3-benzothienyl, 2-thienyl, 2-thiazolyl, pyridyl, 2-quinolyl, indolyl, ethylbenzene, naphtyl, p-aminobenzyl, p-azidobenzyl, p-bromobenzyl, p-hydroxyphenyl, p-tert-butylbenzyl, p-carboxybenzyl, p-chloro-benzyl, p-cyanobenzyl, 3,4-dichlorobenzyl, p-fluorobenzyl, p-iodobenzyl, p-nitrobenzyl, pentafluorobenzyl, p-phenylbenzyl, m-fluorobenzyl, p-methyl-benzyl, tryptoline-3-carboxylic acid, methyl-tryptophan, methyl-1H-indolyl, 2-amino-4-ethyl-phenol, 2,6-dibromo-4-ethyl- phenol, 4-ethyl-2,6-diiodo-phenol, l-ethoxy-4-ethyl-benzene, l-ethyl-4-methoxy-benzene, 4-ethyl-2-iodo-phenol, (4-ethyl-phenyl)-phenyl-methanone, 1-thiophen-2-yl-ethanol, l,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid, 7-hydroxy-l,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid, sulfuric acid mono-(4-ethyl-phenyl)ester, phosphoric acid mono-(4-ethyl-phenyl)ester, 4-ethyl-2-nitro-phenol, l-tert-butoxy-4-ethyl-benzene and 4-(4-ethyl-phenoxy)-phenol. |
