发明名称 |
HCV NS-3 SERINE PROTEASE INHIBITORS |
摘要 |
Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formulawhere the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site. |
申请公布号 |
EA014584(B1) |
申请公布日期 |
2010.12.30 |
申请号 |
EA20060001400 |
申请日期 |
2005.01.28 |
申请人 |
MEDIVIR AB;TIBOTECH PHARMACEUTICALS LTD. |
发明人 |
ROSENQUIST ASA;THORSTENSSON FREDRIK;JOHANSSON PER-OLA;KVARNSTROM INGEMAR;SAMUELSSON BERTIL;WALLBERG HANS |
分类号 |
C07K5/02;A61K31/47;A61P31/12;C07C235/40;C07C237/04;C07C237/10;C07C247/04;C07C271/22;C07C281/02;C07C309/73;C07C311/51;C07D;C07D207/16;C07D215/22;C07D215/233;C07D245/04;C07D401/12;C07D405/14;C07D409/14;C07D413/14;C07D417/04;C07D417/14;C07D487/04;C07K5/06 |
主分类号 |
C07K5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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