| 摘要 |
The present invention relates to water-insoluble matrix tablets which are capable of prolonged release of active principles liable to be diverted for drug addiction purposes. The water-insoluble matrix tablets comprise at least one excipient may be subject to drug abuse dispersed within a compression matrix, said matrix comprising at least one excipient chosen from the group comprising sustained-release, pH-independent, water-insoluble polymers, mineral excipients and their mixtures, wherein the quantity of excipient and the compression conditions are chosen so that said tablets have a crush resistance of at least 4 MPa, advantageously at least 6 Mpa, wherein polymers are selected from the group comprising a mixture of microcrystalline cellulose and [polyvinyl acetate/polyvinylpyrrolidone (80:20)] and the mixture of microcrystalline cellulose and [poly(ethylacrylate/methylmethacrylate/trimethyl-amonioethyl methacrylate chloride) (1:2:0.2)]. |
