发明名称 |
AQUEOUS BASED PHARMACEUTICAL FORMULATIONS OF WATER-SOLUBLE PRODRUGS OF PROPOFOL |
摘要 |
The present invention is directed to aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol and an effective amount of an antioxidant. In one embodiment, the formulation also contains a tonicity modifier. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. Advantageously, the formulations can be prepared without the use of harmful co-solvents or surfactants, and are stable at room temperature over extended periods of time. |
申请公布号 |
IL208697(D0) |
申请公布日期 |
2010.12.30 |
申请号 |
IL20100208697 |
申请日期 |
2010.10.14 |
申请人 |
EISAI INC.;EISAI CORPORATION OF NORTH AMERICA |
发明人 |
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分类号 |
A61K9/08;A61K;A61K9/00;A61K31/05;A61K31/661;A61K47/02;A61K47/10;A61K47/12;A61K47/16;A61K47/18;A61K47/20;A61K47/22;A61K47/26;A61K47/42;A61P23/00;A61P25/20;A61P43/00 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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