CRYSTAL OF XPA AND ERCC1 COMPLEX AND USES THEREOF

摘要

The present invention relates to complexes and crystals of an XPA peptide and an ERCC1 peptide, and structural coordinates of the complex obtained from such crystals. The coordinates are useful for identifying compounds that bind to ERCC1 and inhibit binding of XPA, and thus inhibitors of nucleotide excision repair (NER). The NER inhibitors are used for treating neoplastic diseases, cancer, and hyperproliferative disorders.