ULTRASENSITIVE DETECTION OF BIOMOLECULES USING IMMUNOSEPARATION AND DIFFRACTOMETRY

摘要

Systems and methods for rapid and ultrasensitive detection of target hiomolecules in a sample are presented. The detection of biomolecules is achieved through a synergistic use of immunoseparation and diffractomctry, and the formation of antibody-biomolecule-ligand sandwich complexes that form diffraction gratings. Characteristic diffraction patterns are then produced upon illumination of the diffraction gratings with light. The diffraction patterns can he used to detect very low amounts of biomolecules present in the sample.