| 发明名称 |
ANTIBODIES TO SCLEROSTIN AND METHOD FOR USE THEREOF |
| 摘要 |
The present invention relates to an antibody, or an antigen-binding fragment thereof, that binds specifically to a sclerostin polypeptide, said sclerostin polypeptide and are capable to increase bone density or to minerals content in mammal bones. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures. |
| 申请公布号 |
EA014525(B1) |
申请公布日期 |
2010.12.30 |
| 申请号 |
EA20060000037 |
申请日期 |
2004.06.15 |
| 申请人 |
U.C.B. MANUFACTURING, INC. |
发明人 |
BRUNKOW MARY, E.;GALAS DAVID, J.;KOVACEVICH BRAIN;MULLIGAN JOHN, T.;PAEPER BRYAN, W.;VAS NESS JEFFREY;WINKLER DADID, G. |
| 分类号 |
C07K14/435;A61K48/00;A61P19/00;A61P19/10;C07K14/51;C07K16/18;C07K16/22;C12N5/12;C12Q1/68;G01N33/68 |
主分类号 |
C07K14/435 |
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