发明名称 |
GUANIDINE BASED COMPOUNDS |
摘要 |
The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into α and &bgr; subclasses. The adrenoceptors have important roles in regulating a myriad of physiological conditions and their malfunction has been implicated in the pathophysiology of a number of diseases. Disclosed herein are a series of novel guanidine and 2-aminoimidazoline compounds which are ligands of the alpha2-adrenoceptor (α2-ARs) subclass of adrenergic receptors. The invention also provides for pharmaceutical compositions comprising the novel compounds. The compounds are suitable for use in the manufacture of medicaments for the treatment of α2-ARs associated disorders, such as depression, schizophrenia, glaucoma and analgesia.
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申请公布号 |
US2010331384(A1) |
申请公布日期 |
2010.12.30 |
申请号 |
US20080809843 |
申请日期 |
2008.12.22 |
申请人 |
UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA;THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND;UNIDIVIDED TRINITY OF QUEEN ELIZABETH |
发明人 |
ROZAS HERNANDO MARIA ISABEL;ROYO FERNANDO RODRIGUEZ;MEANA JAVIER;CALLADO LUIS |
分类号 |
A61K31/4178;A61K31/155;A61K31/4168;A61P9/12;A61P25/00;A61P25/18;A61P25/24;A61P27/06;C07C279/18;C07D233/50;C07D403/12 |
主分类号 |
A61K31/4178 |
代理机构 |
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