Activin receptor-like kinases, proteins having serine threonine kinase domains and their use

摘要

A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-&bgr;-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain VIB and/or a GTKRYM sequence in subdomain VIII.