QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS

摘要

Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia):a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein Ris hydrogen, halo, Ar or alkyl; p is 1, 2, 3 or 4; Ris alkyloxy, alkylthio or a radical of formula;wherein Y is O; Ris alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; Rand Rare independently hydrogen, alkyl or benzyl; or Rand Rtogether and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl; Ris hydrogen, halo, Ar, alkyl or alkyloxy; optionally substituted by alkyl or mono- or dialkylamino; r is 1,2, 3, 4 or 5; Ris hydrogen; alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms;wherein R, R, R, R, R, R, R, p and r are as defined in claim 1 and wherein q is 0, 1 or 2.