发明名称 |
Interaction Between the VHL Tumour Suppressor and Hypoxia Inducible Factor, and Assay Methods Relating Thereto |
摘要 |
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor α subunits, by targeting HIF α for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF α subunit sequences which may modulate this interaction.
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申请公布号 |
US2010330668(A1) |
申请公布日期 |
2010.12.30 |
申请号 |
US20100726145 |
申请日期 |
2010.03.17 |
申请人 |
ISIS INNOVATION LIMITED |
发明人 |
RATCLIFFE PETER JOHN;MAXWELL PATRICK HENRY;PUGH CHRISTOPHER WILLIAM |
分类号 |
C12N5/071;G01N33/50;A61K38/00;A61P9/00;C07K7/06;C07K7/08;C07K14/00;C07K14/47;C07K14/705;C12N5/06;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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