发明名称 |
Protein-carrier conjugates |
摘要 |
The invention provides compositions and methods for covalent attachment of polymer and lipid carriers to therapeutic proteins to form carrier-protein conjugates having linkers between the carrier and protein portions of the conjugates. The linkers are selected to minimize steric effects. The linkers reduce the shielding effect of the carrier on the therapeutic protein and also allow better access for enzymatic or chemical cleavage of the carbamate bond. The linkers attach to the therapeutic protein via a carbamate bond and are either directly adjacent to the carbamate bond or are separated by a single carbon having a nitrogen side chain. Such linkers are solely comprised of carbon, sulfur and hydrogen and are between four and ten atoms (either C or S) in length.
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申请公布号 |
US2010330033(A1) |
申请公布日期 |
2010.12.30 |
申请号 |
US20100799006 |
申请日期 |
2010.04.15 |
申请人 |
WU NIAN;KELLER BRIAN CHARLES |
发明人 |
WU NIAN;KELLER BRIAN CHARLES |
分类号 |
A61K38/21;A61K38/28;A61P3/10;C07K17/08 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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