发明名称 |
ZAP-70 AS PREDICTOR AND MODULATOR OF EFFECTOR FUNCTION OF T CELLS |
摘要 |
In this application is described a novel, multiparameter analysis of TCR-coupled signaling and function in resting and activated naive and memory CD4 T cells, revealing a biochemical basis for immunological recall. Results reveal a novel biochemical signature imparted to memory CD4 T cells enabling efficacious responses through increased ZAP-70 expression and reduced accumulation of downstream signaling events.
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申请公布号 |
US2010331391(A1) |
申请公布日期 |
2010.12.30 |
申请号 |
US20080733636 |
申请日期 |
2008.09.10 |
申请人 |
CHANDOK MEENA;FARBER DONNA;OKOYE FRANCESCA |
发明人 |
CHANDOK MEENA;FARBER DONNA;OKOYE FRANCESCA |
分类号 |
A61K31/713;A61K31/05;A61P37/06;C12N5/0783;C12Q1/02 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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