MATERIALS AND METHODS FOR THE IDENTIFICATION OF DRUG-RESISTANT CANCERS AND TREATMENT OF SAME

摘要

Disclosed herein are diagnostic methods for identifying cancer and predicting drug resistance. The assays involve the detection of NEK2 gene expression alone or in combination with other genes or clinical factors. The test is suitable for diagnosing and monitoring treatment of subjects having or suspected of having a neoplastic disease, such as multiple myeloma. The disclosure also relates to inhibitors of NEK2 for the treatment of cancer, including drug-resistant multiple myeloma.