URATE TRANSPORTER, AS WELL AS METHOD AND KIT FOR EVALUATING URATE TRANSPORT-RELATED DISEASE FACTOR AND INFLAMMATION-RELATED DISEASE FACTOR, AND TEST SAMPLE AND DRUG

摘要

Provided is a method for evaluating urate transport-related disease factor and inflammation-related disease factor, in which a high-capacity urate transporter is identified in order to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease on the basis of the identified transporter. Also provided are an evaluation kit which implements this method, a test sample, and a drug. A urate transporter capable of selectively and ATP-dependently emitting urate is formed from proteins having ABCG2. The method for evaluating urate transport-related disease factor and inflammation-related disease factor comprises a step for detecting variations in genes that encode the ABCG2 protein using a sample containing the human genes of the subject. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.