SYSTEMIC PRO-HEMOSTATIC EFFECT OF CLOTTING FACTORS IN COMBINATION WITH SYMPATHICOMIMETICS WITH AGONISTIC EFFECTS ON a-ADRENERGIC AND/OR ß-ADRENERGIC RECEPTORS OF THE SYMPATHETIC NERVOUS SYSTEM, RELATED TO IMPROVED CLOT STRENGTH.

摘要

The present invention relates to a novel use and methods of treatment using the combination of clotting factors and sympathicomimetic / adrenergic receptor agonists with pro-hemostatic activity. Administration of a combination of clotting factors and sympathicomimetic / adrenergic receptor agonists increases blood clot strength as visualized by TEG analyses. The compounds of the invention are particularly useful in the treatment of trauma patients.