VIRUS-LIKE PARTICLE VECTOR AS A POLYVALENT PLATFORM FOR INTRACELLULAR DELIVERY OF HIGH-MOLECULAR-WEIGHT THERAPEUTIC SUBSTANCES, METHOD FOR GENERATING A VIRUS LIKE PARTICLE VECTOR AND USE OF A VIRUS-LIKE PARTICLE VECTOR AND A PHARMACEUTICAL COMPOSITIO

摘要

The invention relates to a virus-like particle vector, a method for production of said vector, use of said vector and a pharmaceutical composition containing said virus-like particle vector. More particularly, the invention relates to a protein virus-like-particle vector which is adenovirus dodecahedron (Dd) and delivering therapeutic substances belonging to classes of proteins, peptides, polysaccharides, nucleic acids, lipids, lipoproteins, or derivatives thereof, to mammalian cells. This invention allows for production of human or animal vaccines, delivery of antibodies, antitumour proteins, antitumour agents, nucleic acids, enzymes and immunosuppressive agents, as well as proteins/peptides and lipids determining specific tissue tropism or nucleic acids, to mammalian cells. According to the method of the invention, the WW domains that form a universal linker for the vector are derived from fungal proteins, especially from the proteins of yeast.