CATIONIC LIPOSOMES FOR THE DELIVERY OF HIGH MOLECULAR WEIGHT COMPOUNDS

摘要

The present invention relates to a specific type of liposomes, denominated as SECosomes, made from a cationic lipid such as 1, 2-dioleoyl-3-trimethylammonium propane (DOTAP), a surfactant such as sodium cholate (NaChol), a stabilizer such as cholesterol or a derivate thereof, and, an alcohol such as ethanol. Said liposomes are capable of delivering high molecular weight compounds, such as siRNAs, efficiently across tissues and into cells of tissues, such as skin.