发明名称 |
MZB1, A NOVEL B CELL FACTOR, AND USES THEREOF |
摘要 |
<p>The marginal zone (MZ) and B1 subsets of B cells, which differ from conventional follicular (FO) B cells both developmentally and functionally, are involved in early responses to infectious pathogens and the production of self-reactive antibodies. A novel gene, mzb1 , is expressed at high levels in MZ and B1 B cells but at low level, if at all, in FO B cells. MZB1 is involved in the regulation of proliferation, BCR-mediated signal transduction, and antibody production in B cells. Inhibitors, activators and enhancers of MZB1 expression or activity can be used as immune modulators for research and therapeutic purposes.</p> |
申请公布号 |
EP2265636(A1) |
申请公布日期 |
2010.12.29 |
申请号 |
EP20090727116 |
申请日期 |
2009.03.31 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
GROSSCHEDL, RUDOLF;FLACH, HENRIK;KIM, SOLA;DUCHNIEWICZ, MARLENA;SCHREINER, BERNADETTE;ROSENBAUM, MARC |
分类号 |
C07K16/18;A61K38/00;C07K14/475 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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