发明名称 |
METHOD FOR PROMOTING IMMUNE RESPONSE COMPRISING INHIBITING CD22 FUNCTION IN B CELLS |
摘要 |
The purpose of the present invention is to elucidate a relationship between deregulation of signaling by CD22 and a rapid response of B cells by IgG-BCR and the like, and to provide a method capable of inducing a rapid immune response and defending against infection instead of vaccine. The present invention relates to a method for promoting an immune response causing such a strong proliferation of clones and production of a large amount of antibody-producing cells as those seen in the memory immune response even in the naive B cells expressing IgM-BCR and IgD-BCR by inhibiting The CD22 function in B cells; and to a method for screening a substance capable of promoting the immune response based on a change in the CD22 function in B cells. |
申请公布号 |
EP2098246(A4) |
申请公布日期 |
2010.12.29 |
申请号 |
EP20070851040 |
申请日期 |
2007.12.21 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
TSUBATA, TAKESHI;ONODERA, TAISHI |
分类号 |
A61K45/00;A61K39/00;A61K39/395;A61P37/04;C12N5/10;C12N15/09;C12P21/08;C12Q1/02;G01N33/15;G01N33/50 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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