发明名称 |
Topoisomerase-targeting agents |
摘要 |
The invention provides compounds of formula I or formula II: wherein: the bond represented by is a single bond or a double bond, and R1—R5, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I or II, processes for preparing compounds of formula I or II, intermediates useful for preparing compounds of formula I or II, and therapeutic methods for treating cancer and other topoisomerase related conditions using compounds of formula I or II.
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申请公布号 |
US7858627(B2) |
申请公布日期 |
2010.12.28 |
申请号 |
US20090422394 |
申请日期 |
2009.04.13 |
申请人 |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY |
发明人 |
LAVOIE EDMOND J.;RUCHELMAN ALEXANDER L.;LIU LEROY F. |
分类号 |
A61K31/4355;A61K31/5025;C07D487/04;C07D487/14;C07D491/04;C07D491/056;C07D491/147 |
主分类号 |
A61K31/4355 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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