发明名称 |
Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal |
摘要 |
The instant invention is drawn to a hepatocyte targeted composition comprising a mixture of free recombinant human insulin isophane and free Recombinant human regular insulin insulin and a mixture of recombinant human insulin isophane and Recombinant human regular insulin insulin associated with a water insoluble target molecule complex, wherein the complex comprises multiple linked individual units and a supra-molecular lipid construct matrix. Recombinant human insulin isophane and Recombinant human regular insulin insulin are present within the complex in at least one form wherein the recombinant human insulin isophane and Recombinant human regular insulin insulin have regions of positive charge which interacts with a negative charge on the complex. The invention also includes methods for the manufacture of the composition and methods of managing blood glucose levels in individuals with Type I and Type II diabetes.
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申请公布号 |
US7858116(B2) |
申请公布日期 |
2010.12.28 |
申请号 |
US20060384659 |
申请日期 |
2006.03.20 |
申请人 |
SDG, INC. |
发明人 |
LAU JOHN R.;GEHO W. BLAIR |
分类号 |
A61K9/127;A61K9/133;A61K38/28;A61K47/02;A61K49/00;A61K49/18 |
主分类号 |
A61K9/127 |
代理机构 |
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地址 |
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