发明名称 Lactams and uses thereof
摘要 Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid &bgr; protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid &bgr; protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
申请公布号 US7858776(B2) 申请公布日期 2010.12.28
申请号 US20090359465 申请日期 2009.01.26
申请人 ASTRAZENECA AB 发明人 DEMBOFSKY BRUCE THOMAS;JACOBS ROBERT;OHNMACHT CYRUS
分类号 C07D223/16;A61K38/00;A61P25/28;C07D267/10;C07D267/14;C07D281/06;C07D281/10;C07D405/04;C07D417/12;C07D417/14;C07K5/06 主分类号 C07D223/16
代理机构 代理人
主权项
地址