METHOD FOR PREPARATION OF BETA-AMINO CARBONYL COMPOUND USING CHIRAL CATALYST

摘要

PURPOSE: A method for preparing beta-amino carbonyl compound is provided to efficiently produce optically active substance of high optical purity. CONSTITUTION: A beta-amino carbonyl compound is prepared by reacting imine compound with alpha-cyano ketone or beta-ketoester compound under the presence of chiral catalyst. The chiral catalyst is a chiral bifunctional organic catalyst in which urea and amine group are combined or chiral bifucntional organic catalyst in which thio urea and amine group are combined. The alpha-cyano ketone compound has a structure of chemical formula 2; chiral catalyst has a structure of chemical formula 1; beta-ketnoester compound has a structure of chemical formula 3; and imine compound has a structure of chemical formula 4.