Heterogeneous foldamers containingα,β, and/orγ-amino acids

摘要

Disclosed are isolated, unnatural polypeptides containing cyclically-constrained &bgr;-amino acid residues and cyclically-constrained γ-amino acid residues. The compounds are unnatural and because they contain rotationally constrained residues that are not amenable to enzymatic degradation, the compounds are useful to probe protein-protein and other large molecule interactions.