发明名称 |
IN VIVO TEMPORAL CONTROL OF ACTIVATABLE MATRIX-DEGRADING ENZYMES |
摘要 |
<p>Methods and combinations are provided for controlling the duration of action, in vivo, of matrix-degrading enzymes. The methods and combinations permit temporary in-vivo activation of matrix-degrading enzymes upon administration to the extra cellular matrix (or“ECM”). Matrix-degrading enzymes having a controlled duration of action can be used to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.</p> |
申请公布号 |
KR20100135779(A) |
申请公布日期 |
2010.12.27 |
申请号 |
KR20107022203 |
申请日期 |
2009.03.06 |
申请人 |
HALOZYME, INC. |
发明人 |
KELLER GILBERT A.;FROST GREGORY I. |
分类号 |
A61K38/48;A61P1/00;A61P17/02;A61P19/02 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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