ALKALOID COMPOUNDS AS ACTIVATORS OF DDAH PROMOTER FROM EVODIA RUTAECARPA AND COMPOSITIONS FOR PREVENTION AND TREATMENT EFFECTS OF ISLET CELLULAR APOPTOSIS AND DIABETIC NEPHROPATHY CONTAINING THE SAME AS AN ACTIVE INGREDIENT

摘要

PURPOSE: A composition containing alkaloids-containing Evodia rutaecarpa extract is provided to enhance activation of DDAH(dimethylarginine dimethylaminohydrolase) and to prevent or treat pancreatic beta cell apoptosis and diabetic nephropathy. CONSTITUTION: A composition for preventing or treating pancreatic beta cell apoptosis and diabetic nephropathy contains Evodia rutaecarpa extract. The Evodia rutaecarpa extract is obtained by exrtracting Evodia rutaecarpa with ethanol solvent and concentrating. The Evodia rutaecarpa extract contains evodiamine, rutaecarpine, 7-hydroxyrutaecarpine, norketoyobyrine, or ketoyobyrine compound.