Synthetic membrane anchors

摘要

Disclosed are synthetic molecules that spontaneously and stably incorporate into lipid by-layers, including cell membranes. The molecules are of the structure F-S1-S2-L where F is a glycotope; S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is -CO(CH2)3CO-, -CO(CH2)4CO-, or -CO(CH2)5CO-; and L is a diacyl- or dialkyl- glycerophospholipid. The molecules can be used as synthetic membrane anchors or synthetic molecule constructs to effect qualitative and quantitative changes in the expression of cell surface antigens.