Pyrazine derivatives for inhibiting RAF activity

摘要

Disclosed is an aminopyrazine derivative of formula (I), wherein W is -NRN4-, -O-, or -S-, RN4 is H or C1-4alkyl, Y is an optionally substituted carbocycle or heteroaryl, Z is optionally substituted phenyl, and wherein the optional substituents are as defined in the specification. Also disclosed by the specification are pyrazine and pyridine derivatives of formula (II), wherein Q is N or CH, and wherein the other substituents are as defined in the specification. Also disclosed is the use of any of the above compounds for inhbiting RAF activity and for treating conditions ameliorated by the inhibition of RAF, such as cancer, melanoma, or malignant melanoma.