| 摘要 |
Pyrazolo-pyrazine derivatives (I) and their diastereomers or salts are new. Pyrazolo-pyrazine derivatives of formula (I) and their diastereomers or salts are new. Either R 1>, R 2>H, aryl or heteroaryl (both optionally substituted by halo, alkyl or alkoxy) (where R 2>is preferably H); or R 1>R 2>cycle or heterocycle; R 3>1-8C alkyl, cycloalkylalkyl, aryl or arylalkyl; R 4>H (preferred) or -COOR 5>; R 5>alkyl, methylfluorene or benzyl; n : 1 or 2; X : S or Se; and Z : H. [Image] - ACTIVITY : Cytostatic; Neuroprotective; Antiparasitic; Virucide; Endocrine-Gen; Immunosuppressive; Antiinflammatory; Antiallergic; Antidiabetic; Anorectic. - MECHANISM OF ACTION : G protein inhibitor.
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