| 摘要 |
PROBLEM TO BE SOLVED: To provide new neurologically-active compounds. SOLUTION: There are provided neurologically-active compounds which are heterocyclic compounds having two fused 6-membered rings with a nitrogen atom at position 1 and a hydroxy or mercapto group at position 8 with at least one ring being aromatic. For example, 8-hydroxy-4(3H)-quinazolinone, 8-hydroxy-quinazoline, 8-hydroxy-quinoxaline, [1, 6]naphthyridin-8-ol, 9-hydroxypyrimido[1, 6-a]pyrimidin-4-one, 8-hydroxy-cinnoline, 6-hydroxy-phenazine, 4-hydroxy-acridine, 4,7(4, 10)-phenanthrolin-5-ol and the like are provided. Also there are provided processes for the preparation of the compounds and their use as pharmaceuticals or veterinary agents, specifically for neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease. COPYRIGHT: (C)2011,JPO&INPIT |
