| 发明名称 |
PEG-Urate Oxidase Conjugates and Use Thereof |
| 摘要 |
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
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| 申请公布号 |
US2010323422(A1) |
申请公布日期 |
2010.12.23 |
| 申请号 |
US20100769570 |
申请日期 |
2010.04.28 |
| 申请人 |
WILLIAMS L DAVID;HERSHFIELD MICHAEL S;KELLY SUSAN J;SAIFER MARK G P;SHERMAN MERRY R |
发明人 |
WILLIAMS L. DAVID;HERSHFIELD MICHAEL S.;KELLY SUSAN J.;SAIFER MARK G. P.;SHERMAN MERRY R. |
| 分类号 |
C12N9/96;A61K38/00;A61K38/44;A61K47/48;C12N1/21;C12N9/02;C12N9/06 |
主分类号 |
C12N9/96 |
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