| 摘要 |
A Ganoderma tsugae active substance, produced from Ganoderma tsugae by following steps: (1) liquid culturing Ganoderma tsugae; (2) extracting the fermentation filtrate obtained with ethanol to obtain ethanol extraction precipitate; (3) purifying the ethanol extraction precipitate obtained by gel filtration chromatography to obtain gel filtration chromatographed product; and (4) extracting the gel filtration chromatographed product obtained with acetone to obtain the supernatant as the desired Ganoderma tsugae active substance. The invention provides further a composition comprising Ganoderma tsugae active substance produced by the above-described steps, said composition is useful for inducing or increasing the quantity of intranuclear transcription factor Nrf2, promoting the activities of antioxidant response element promoter (ARE promoter) and Thioredoxin reductases promoter (TrxR promoter), and inducing expressions of Heme oxygenase-1 (HO-1) and Thioredoxin reductases (TrxR), so as to achieve effects of protecting cell or preventing atherosclerosis.
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