发明名称 |
FUSION PROTEIN CAPABLE OF BINDING VEGF-A AND TNF-ALPHA |
摘要 |
The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1. |
申请公布号 |
WO2010067339(A3) |
申请公布日期 |
2010.12.23 |
申请号 |
WO2009IB55718 |
申请日期 |
2009.12.11 |
申请人 |
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY;JUNG, KEEHOON;KOH, YOUNG JUN;KIM, SUN CHANG;KOH, GOU YOUNG |
发明人 |
JUNG, KEEHOON;KOH, YOUNG JUN;KIM, SUN CHANG;KOH, GOU YOUNG |
分类号 |
C07K19/00;A61K38/00;A61P3/00;A61P19/02;C12N15/62;C12N15/63 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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