发明名称 |
NANOPLASMONIC MOLECULAR RULER FOR NUCLEASE ACTIVITY AND DNA FOOTPRINTING |
摘要 |
This invention provides a nanoplasmonic molecular ruler, which can perform label-free and real-time monitoring of nucleic acid (e.g., DNA) length changes and perform nucleic acid footprinting. In various embodiments the ruler comprises a nucleic acid attached to a nanoparticle, such that changes in the nucleic acid length are detectable using surface plasmon resonance. The nanoplamonic ruler provides a fast and convenient platform for mapping nucleic acid -protein interactions, for nuclease activity monitoring, and for other footprinting related methods.
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申请公布号 |
US2010323906(A1) |
申请公布日期 |
2010.12.23 |
申请号 |
US20070440579 |
申请日期 |
2007.09.14 |
申请人 |
CHEN FANQING FRANK;LIU GANG L;LEE LUKE P |
发明人 |
CHEN FANQING FRANK;LIU GANG L.;LEE LUKE P. |
分类号 |
C12Q1/68;C07H21/02;C07H21/04;C40B30/04;C40B40/08 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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