AN IMPROVED PROCESS FOR THE PREPARATION OF IMIPENAM

摘要

A process for the preparation of Imipenem (formula (I)) or its hydrates comprising (i) deprotection of a carboxylic ester via catalytic hydrogenation in the presence of a catalyst deactivating agent and/or (ii) rapid dissolution of Imipenem in water at high temperature, followed by rapid cooling and isolation of the Imipenem in order to improve yield and purity and facilitate preparation of sterile Imipenem.